Abstract: By means of influence factors correction and trend fitting analysis methods, this paper studied the characteristics of geochemical background and geochemical anomaly distribution in Meath Braque area in Kuqa depression of Tarim basin. The results show that lines along Heiying?1well?Meath Braque?Carlo Kangxia, Sarah Hitam?Heiyingshan, and near Manchu Tamu have high value of geochemical explorative index, also they are the main distribution areas of geochemical anomaly. According to the anomaly level, combination and configuration relationship of the single geochemical index, it was divided into sixteen comprehensive anomalies. Based on the structural position, distribution and combination relationships of these geochemical anomalies, this area was divided into five comprehensive anomalies regions, among which there are only one most favorable area and two favorable areas. Integrated with the oil and gas geologic conditions in this area, it is suggested that the central annular anomaly zone could be the most favorable area for further petroleum exploration