Abstract: The thrust fold belt in southern margin of Junggar basin has been still active since the Cenozoic era, and the hydrocarbon exploration in this area must focus in present thrust structural belt rather than ancient one. Based on available surface surveys and 2D/3D seismic data interpretations, the dip angles of thrust faults in this belt most range from 30°±5° to 50°±5°. The stress analysis shows that intersection angle between the principal stress and the fault is about 30°±5°, which means the maximum/the minimum principal stress ratio is the minimum, there exists the maximum fluid pressure, at which the fluids around the fault may flow along the maximum principal stress orientation,the faults become the main pathway of fluid migration. When the intersection angle is about 50°±5°, the reactivated faults need higher fluid pressure, resulting in that the sealing of the fault is relatively better. Under the tectonic compression, the thrust fault extends toward the north,in which the detachment layer of fault is mudstone or shale of the Paleocene Anjihaihe formation, which forms much higher tectonic overpressures in this layer. The sandstone horizontal permeability of the Ziniquanzi formation underlying Anjihaihe formation is much higher than its vertical permeability, which is helpful to becoming favorable reservoirs, being major target zones for petroleum exploration in this area