Abstract: The role of deep profile control is to improve the reservoir heterogeneity and enhance the efficiency of waterflooding. Several agents performances were evaluated, and 4?well group pilot test was conducted for deep profile control in eastern TI oil layer in Wellblock?2 of Lunnan oilfield in Tarim basin. The laboratory studies show that the microsphere and particle are of better performances of high temperature and salt resistance, and the high temperature?resisting polymer is of good water shutoff performance. The field pilot test shows that with increase of the 4?well group water injection pressure, the average apparent injectivity index may decrease by 12.5%. By the end of Feb.2014, the cumulative incremental oil of the test area reached 1.23×104 t, the incremental oil for slowdown decline was 2.22×104 t, and the water cut decreased by 3.2%. The obvious effects indicate that the successful application of the deep profile control technology to the pilot test area is of implication for development of the whole TI reservoir and other ones with high temperature and high salinity