Abstract: On the basis of considering multiple migration mechanisms, a nano-pores gas flow model and an apparent-permeability model are established for shales, based on which a gas reservoir-fracture-wellbore coupled flow model is established through fracture space dispersion and by means of pressure drawdown superposition principle, and matrix analysis method and numerical iteration method are used to solve the model. The factors influencing the productivity of zipper-like fracturing horizontal wells in shale gas reservoirs are analyzed by the model. The result shows that the production considering the microscopic flow of shale gas is higher than that without considering the microscopic flow. Slipping flow contributes the most to the gas production with the secondary of surface diffusion and Knudsen diffusion makes the minimum contribution. The incremental gas production gradually decreases with the increase of well spacing, and there is an optimal value of well spacing. The larger the overlap ratio of stimulated reservoir volume is, the less the gas production will be, but there is an optimal overlap ratio of stimulated reservoir volume with the gradual increase of amplitude of gas production decrease