Abstract: Previous technologies for horizontal well track and staged fracturing optimization in carbonate reservoirs could not be used to predict the complexity of reservoir stimulation and the connections of favorable fractures around wellbores, due to lack of comprehensive analysis data of in-situ stress. On the basis of reservoir in-situ stress characteristics, a 3D in-situ stress model based on wave impedance inversion data cubes is established for the carbonate reservoirs, which integrates horizontal well track and staged fracturing optimization technologies, including the drilling rate of fracture zones, borehole stability and reservoir stimulation at the late stage. The method is applicable for heterogeneous carbonate reservoirs in Tazhong area, Tarim basin and can provide basis for horizontal well track design and staged fracturing stimulation