Abstract: The sandstone reservoir CⅢ in Well Donghe1-10H of Donghe oilfield is characterized by poor physical property, high water cut, long horizontal section and low pressure coefficient. During drilling and workover operations, contamination occurred to the reservoir because of the uneven acid distribution and incomplete flowback of residual acid in the reservoir when applying conventional acidification, resulting in the poor acidizing effect in oil zones. Based on which, the paper proposed a foam acidizing method to remove plugging and performed core foam diversion acidizing experiments. The results show that the foaming ability and stability of the foam acid are pretty good and the foam can effectively plug the aquifer; the difference of the diversion flow rates in the high-permeability core and low-permeability core decrease from 19 times before foam acid injection to 1.7 times after the experiment. The actual field application of foam acidizing and plugging removal technology in the wellsite of Donghe 1-10H indicates a good stimulation effect. The technology can effectively solve the reservoir contamination in Well Donghe 1-10H and provides technical support for the oil production of horizontal well in the oilfield