Abstract: Aiming at the fact that universal high miscible pressures existed in domestic reservoirs by CO2 flooding technology available in China tend to resulting in poor miscible displacement, and low target oil recovery efficiency, this paper drew the experiences from available structural characteristics of surfactants applied in microemulsion of CO2?water systems, by taking fluoro?alkane chains and non?fluoro?OAc chains as the CO2?philic ends, taking alkane structure as the lipophilic ends, designed the synthetic organic assistants (aids). The aids’effects for reducing CO2?crude oil interfacial tension and minimized miscible pressure of CO2 flooding were analyzed and optimized by surface tension testing in CO2?kerosene system and CO2?crude oil system. The aids’effects for reducing CO2?crude oil interfacial tension and minimized miscible pressure (MMP) of CO2 flooding were analyzed and optimized by surface tension testing in CO2?kerosene system and CO2?crude oil system. The result shows that the new two aids with per?acetylated glucose dodecyl ester molecules and citric acid isopropyl ester molecules do have better miscible processing effects for minimizing the interfacial tension of the CO2?crude oil system and reducing the MMP. The case study suggests that per?acetylated glucose dodecyl ester could cause the surface tension down averagely by28.7% and the MMP of CO2flooding down by27.47%, possessing the value of further research in support of engineering application