Abstract: The correct prediction of formation pressure as dirrect basis of drilling well bore structure, mud quality and drilling parameter design is of great significance to high quality, efficient and safety drilling, reducing downhole complex problem, preserving oil?gas zones,well cementation and completion. The piedmont of Tarim basin was of limitations of geology, seismic data and related knowledges, so the correct prediction of pre?drilling formation pressure was difficult, and the proper drilling engineering implementation was affected. This paper presents the method for proper prediction of strata pore pressure, collapse pressure and fracture pressure by using the pre?drilling formation pressure, drillstem test, corrected pressure prediction model, model parameter modulation, re?calibrating well?corrosing seismic data, establishing non?linear mapping relation and undrilled strata petrophysical information prediction, etc. in order to provide support bases for parameter’s optimization and regulation of next drilling process