Abstract: Through extracting seismic attributes of sub?layers, on the basis of the attributes standardization and optimization, the regression equation between sandstone thickness and seismic attributes of a sub?layer in development area of southwestern Daniudi gas field is established using stepwise regression analysis. The application effects suggest that the seismic amplitude attributes are of obvious correlation with the sandstone thickness in this area. Using the regression equation can quantitatively predict the interwell sandstone thickness, and the prediction accuracy is within setting thickness and higher with the increasing of the thickness