Abstract: The reservoirs in Dabei gas field of Kuqa depression, Tarim basin are characterized by large buried depth, tight lithology, undeveloped matrix pores and developed fractures. The relevant experimental study shows that a strong pressure sensitivity is found in the reservoir of Dabei gas field, and once pressure sensitivity occurs in gas layers, fractures will be closed and permanent damages to reservoir physical property and a sharp decline in production will happen. A static pressure value for reservoir pressure sensitivity in Dabei gas field is determined through core pressure sensitivity test. Based on the obtained tectonic stress field of the gas reservoirs and combining with the actual formation pressure, the formation pressure leading to pressure sensitivity is determined for the gas reservoirs at different structural positions in Dabei gas field. During the production process of the gas field, before the gas reservoir pressure decreases to the pressure sensitivity threshold value, measures should be taken timely to avoid pressure sensitivity, maintain gas production and enhance gas recovery