Abstract: With the development of the Keshen gas field, the number of plugged wells is gradually increasing, and the degree of plugging is becoming more and more serious, which has affected the safe and stable well production and restricted the efficient development of the gas field. Therefore, aiming to the current situation of wellbore plugging and combined with well production performance, in-situ plugging removal situation and systematical analysis of wellbore returns, it is considered that the main factors causing wellbore plugging are scale plug and sand plug, and the plugging mode is divided into three types: scale plug, sand plug and sand-scale mixed plug. According to the characteristics of the three plugging modes and wellbore integrity, four targeted measures are proposed：applying acidizing unplugging technology in the scale plugging wells, applying coiled tubing technology in the sand plugging wells, applying coiled tubing and acidization in the sand-scale mixed plugging wells and replacing pipe string in the pipe string breaking wells. The actual results show that the application of the four measures can effectively dredge the plugged wellbores and meanwhile reduce the production cost