Abstract: Aiming at well location deployment, drilling speed increasing and well-completion production improvement in the Structure KS24 of Kelasu tectonic belt in the piedmont area of Kuqa depression during exploration, an analysis on the three aspects is carried out from the perspective of geology-engineering integration. In the stage of well location deployment, it is predicted that the faults controlling the structure have good sealing and is conducive to oil and gas preservation. On the basis of geological prediction and geomechanical research, the borehole stabilities are identified for shallow high-steep interval, gravel interval, mudstone interval, gypsum interval and fractured sandstone interval, and measures for optimizing drilling fluid performance are proposed. In the well completion stage, according to the geomechanical characteristics, a reasonable production improvement mode is formulated, and the stimulated interval, operation pressure and perforation cluster are optimized. According to the research results, 9 wells such as Well KS24 and Well KS241 etc. have been drilled successively and no abnormalities occur. The drilling speed is increased by 39% in average, which creates a drilling record in Kelasu tectonic belt. Different stimulation methods are adopted in the 5 drilled wells, the average gas well production is 31×104 m3/d, the average open flow capacity is 170×104 m3/d, and both the exploration success rate and high-yield well rate reach 100%. During the exploration practices in the Structure KS24, a procedure of geology-engineering integration study and its application has been established, and has been combined into well location deployment-drilling and engineering integration, which has become an effective mean to solve exploration and development problems under complex geological conditions